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Efficient Development of Orally-Bioavailable Cyclic-Peptide Drugs via Molecular Dynamics + Machine Learning BACKGROUND Cyclic peptides are a promising drug modality, combining beneficial traits from
https://viceprovost.tufts.edu/cyclic-peptide-structure-prediction-structural-ensembles-achieved-molecular-dynamics-and-machine
Digital to Analog Converter Circuit
Technology
A Digital-to-Analog Converter based on Resistive Interpolation Load Prof. Sameer Sonkusale at the Electrical and Computer Engineering Department at Tufts has developed a single chip integrated DAC
https://viceprovost.tufts.edu/digital-analog-converter-circuit
SUMMARY Researchers at Tufts University discovered novel antigens for a gonococcal vaccine through a unique candidate antigen selection strategy. In vivo, these previously unconsidered protein
https://viceprovost.tufts.edu/new-neisseria-gonorrhoeae-vaccine-antigens-expressed-during-natural-mucosal-infection
SUMMARY A Tufts University investigator and their collaborators at R&D Systems Inc., have developed novel IL-38 analogues to treat neuroinflammatory and neurodegenerative diseases like Autism Spectrum
https://viceprovost.tufts.edu/novel-il-38-analogues-are-potent-inhibitors-neuroinflammatory-mediators
SUMMARY A researcher from the Tufts University School of Medicine has developed novel derivatives of Niacin, which do not produce the uncomfortable side effect of flushing and reddening of the skin
https://viceprovost.tufts.edu/novel-non-flushing-niacin-derivatives-and-mimetics
Summary During physical therapy, practitioners often use a variety of measurement devices. All existing approaches fail to establish functional range of motion and anthropomorphic measurements through
https://viceprovost.tufts.edu/portable-physical-therapy-measurement-device
SUMMARY OF PROBLEMCurrently, blood is collected and stored for further analysis on dried blood spot (DBS) cards. Uses include testing expecting mothers for fetal distress, and newborns for metabolic
https://viceprovost.tufts.edu/functional-point-care-dried-blood-spot-cards
Aqueous 2-Phase System for the Separation and Recovery of Mammalian Cells from Contaminated Cultures
Technology
SUMMARYTufts researchers have developed a method to separate cultured mammalian cells from contaminants based on density using aqueous two-phase systems (ATPS) which allows recovered cells to be
https://viceprovost.tufts.edu/aqueous-2-phase-system-separation-and-recovery-mammalian-cells-contaminated-cultures
SUMMARYTufts researchers have developed a device which traverses the gut and collects samples of the microbiome in a way that permits correlation of samples with particular locations from which they
https://viceprovost.tufts.edu/engineered-pill-aka-lab-pill-spatial-sampling-microbiome-and-other-contents-gut
SUMMARYTufts researchers have developed a novel image fusion algorithm with superior performance PROBLEMThe goal of image fusion is to combine multiple source images obtained using different capture
https://viceprovost.tufts.edu/abstract-2012-paper-multiscale-image-fusion-using-adaptive-similarity-based-sensor-weighting-scheme