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This event focused on Tufts' strength in translational research: applying discovery with topics on the four phases of translational research, as well as poster presentations.

Thursday, November 29, 2007

Jean Mayer USDA Human Nutrition Research Center on Aging
711 Washington Street
Boston, MA 02111

Lightning Talk Sessions

Identification: Finding Genetic and Protein Markers for Disease
Implementation: Bringing New Technologies to Clinical Use
Intervention: Halting and Reversing the Progress of Disease
Prevention: Stopping Disease Before it Starts

Research Presentations

Moderated by Diana Bianchi 

From Bench to Bytes to Baby: A Translational Approach to Human Fetal Development
Diana Bianchi

Neuroscience to SoftBots: New Technologies from Ancient Animals
Barry Trimmer

Shape Up Somerville: Changing Communities One Step at a Time
Christina Economos

Identification: Finding Genetic and Protein Markers for Disease

Moderated by Hans-Georg Klingemann 

Novel Biomarkers for the Early Detection of Acute Kidney Injury
Bertrand Jaber

Natriuretic Peptides in Spontaneous Canine and Feline Heart Disease
John Rush

Identification of Molecular Cardiovascular Disease Targets through Human Genetics
Gordon Huggins

The Role of Biorepositories in Identification of Disease Indicators or Sentinel Markers
Richard Friedberg

Translational Bioinformatics
Donna Slonim

Implementation: Bringing New Technologies to Clinical Use

Moderated by Donna Slonim 

Getting Novel Cellular Therapies to the Patient
Hans-Georg Klingemann

Cervical Biomechanics during Pregnancy
Michael House

Optical Technologies for Non-invasive Disease Diagnosis
Irene Georgakoudi

Implementing Technology into the OR
Caroline Cao

Intervention: Halting and Reversing the Progress of Disease

Moderated by Garry Welch 

Heart Failure Models: Estrogen and its Receptors in Cardiac Hypertrophy
Richard Patten

Spontaneous Animal Models of Obesity: Treatment Options
Lisa Freeman

Biological Screening for Smoking as a Deterrent
Douglas Brugge

Intervention to Improve Medication Adherence Related Communication Improves Communication, but not Adherence
Ira Wilson

Prevention: Stopping Disease Before It Starts

Moderated by Douglas Brugge

Preventing Cardiovascular Disease in CKD
Mark Sarnak

Innovative Strategies in the Management of Diabetes
Garry Welch

The Effects of Exercise Training on Functional Performance and Disability in the Elderly
Roger Fielding

Prevention of Functional Loss and Work Productivity Due to Depression
Debra Lerner

Diana Bianchi, MD

Natalie V. Zucker Professor of Pediatrics, Obstetrics and Gynecology, Tufts University School of Medicine, and Vice Chair for Research, Department of Pediatrics, Floating Hospital for Children and Tufts–New England Medical Center. Dr. Bianchi’s laboratory focuses on prenatal genetics. She is studying fetal cells and DNA that cross into the maternal circulation and can be used for noninvasive prenatal diagnosis of genetic conditions. Remarkably, these cells persist in the mother’s blood and organs for decades after the birth of the child. This phenomenon, called fetal cell microchimerism, is associated with autoimmune diseases and may also be an important source of stem cells for repair of tissue injury in the mother.

Christina Economos, PhD

Christina Economos, PhD New Balance Chair in Childhood Nutrition and assistant professor, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University. Professor Economos’s research focus is on the interaction among diet, exercise, body composition, and aging, with an emphasis on techniques that accurately measure and interventions that optimally develop and preserve skeletal muscle and bone mass throughout the lifespan. Her expertise includes working effectively with diverse populations and communities, developing and applying behavior-change strategies with children and families to improve diet and physical activity, and crafting, implementing and evaluating nutrition education curricula.

Barry Trimmer, PhD

Barry Trimmer, PhD Henry Bromfield Pearson Professor of Natural Sciences, Department of Biology, Tufts University; with appointments in the Department of Biomedical Engineering, School of Engineering, and the departments of Neuroscience and Pharmacology and Experimental Therapeutics, School of Medicine. Professor Trimmer’s research focus is on the mechanisms by which soft-bodied animals control their movements. These ideas are being used to construct an entirely new generation of soft-material robots capable of carrying out tasks that are difficult or impossible with conventional technologies. In addition to his work on living systems, Professor Trimmer is the founder (2005) and director of the Tufts Biomimetic Devices Laboratory, which specializes in the application of found biological principles to the design and fabrication of such novel devices.


In vivo Antisense Oligonucleotide Reduction of NPC1 Expression as a Novel Mouse Model for Niemann Pick Type C Associated Liver Disease

Rimkunas, Graham, Crooke, Liscum

Activation of the Calcium Sensing Receptor Stimulates Serum Gastrin and Gastric Acid Secretion in Healthy Subjects

Ceglia, Harris, Rasmussen, Dawson-Hughes

Breast Cancer Metastasis to Bone: Modeling Angiogenesis in the CAM using Tissue Engineering Strategies


A Mouse Model of Human Breast Cancer Metastasis to Tissue-Engineered Bone

Faverman, Moreau, Anderson, Reagan, Kaplan, Rosenblatt

Mouse Models of Human Cancer Metastasis Revealing Osteotropism Gene Signatures

Goldstein, Anderson, Moreau, Rosenblatt

Silencing of a Stem Cell Differentiation Gene (APRIN) in Prostate and Breast Cancers: Promoter Methylation and Microrna Clinical Studies

Pilichowska, Denes, Kyu Kim, Makarovskiy, Carpinito, Geck

Apoptosis in Response to Inhibition of Dipeptidyl Peptidase 2 Defines Low Risk Chronic Lymphocytic Leukemia

Danilov, Danilova, Klein, Huber

Transfection with mRNA for CD19 Specific Chimeric Antigen Receptor Restores NK Cell Mediated Killing of CLL Cells

Boissel, Betancur, Tuncer, Weitzman, Klingemann

Variable Contribution of Different Monoclonal Antibodies to NK Cell-Mediated ADCC Against Primary CLL Cells

Weitzman, Klingemann, Betancur, Boissel, Rabinowitz

Modulation of Lung Molecular Biomarkers by β-Carotene in the Physicians’ Health Study

Liu, Gaziano, Mucci, Wang, Zhang

Inhibitors of STAT3 Prevent Proliferation of Brain Tumor Stem Cells

Sherry, Reeves, Wu, Cochran

G Protein-Activated Inward Rectifier Potassium Channel 4 is a Regulateable Protein; Its Role in Autonomic Neuropathy in Type I Diabetes

Zhang, Park, Madias, Aronovitz, Karas, Galper

Simvastatin Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E Knockout Mice

Zhang, Naggar, Moulton, Park, Galper

Myosin Phosphatase-Rho Interacting Protein Modulation of Vascular Smooth Muscle Phenotype

Crochiere and Surks

Morphometric Measurements and Insulin-Like Growth Factor in Cats with Spontaneously-Occurring Hypertrophic Cardiomyopathy

Yang, Freeman, Rush

The Obesity Paradox in Dogs with Spontaneously-Occurring Heart Failure

Slupe, Freeman, Rush

Relationship between Cachexia and Lymphocyte Subpopulations and Hematologic Parameters in Dogs with Spontaneously-Occurring Congestive Heart Failure

Freeman and Rush

A Comparison of Oral Versus Transdermal Atenolol Administration in Cats

MacGregor, Rush, Rozanski, Boothe, Belmonte, Freeman

Lipid Lowering by Pravastatin Decreases Premature Ventricular Contractions and Ventricular Tachycardia: Gαi2, a Possible Molecular Marker for Predisposition to Arrhythmia

Welzig, Park, Naggar, Karas, Estes, Galper

Preliminary Foundation for in vitro Autosomal-Dominant Polycystic Kidney Disease Model

Rudym, Kaplan, Perrone

Mitochondrial Membrane Potential in Single Cells in Chronic Kidney Disease – Application of the Live Cell Array

Sathi, Padala, Rao, Demello, Arvold, Wikstrom, Molina, Haigh, Balakrishnan, Shirihai

Comparative Analysis of Urinary Biomarkers for the Early Detection of Acute Kidney Injury (AKI) Following Cardiopulmonary Bypass (CPB)

Liangos, Perianayagam, Kolyada, Tighiouart, MacKinnon, Wald, Han, Bonventre, Jaber

Proteomic Research and Services of the Tufts Proteomic Core Facility


STAT Decoy Oligonucleotide Administration Decreases Airway Inflammation and AHR in Allergic Asthma

Simeone-Penney and Simon

Nucleic Acid Microsphere Arrays for Respiratory Pathogen Analysis

Hayman and Walt

Intra-Oral Biofilms in the Complete Denture-Wearing Patient


Substance P Stimulates Human Mast Cells and Together They Activate T Cells: Inhibition by Luteolin

Kempuraj, Tagen, Iliopoulou, Clemons, Vasiadi, Boucher, House, Wolfberg, Theoharides

Microsphere-Based Cytokine Array for Salivary Diagnostics

Blicharz and Walt

Subtilase Cytotoxin (SubAB), a Newly-discovered Cytotoxin Produced by Certain Shiga Toxin-producing Escherichia coli (STEC) Induces a Stress Response in the Endoplasmic Reticulum

Wolfson, May, Thorpe, Jandhyala, J. Paton, A. Paton

Tufts Center for Integrated Tissue Engineering: Translational 3D Human Tissues for Drug Discovery

Egles, Shamis, Garlick

Cell Penetrating Peptide for Delivery of DNA, siRNA and Quantum Dots in vitro and in vivo

Johnson, Cashman, Kumar-Singh

Pomegranate Juice Does Not Impair Clearance of Oral or Intravenous Midazolam: Comparison with Grapefruit Juice

Farkas, Oleson, Zhao, Harmatz, Zinny, Court, Greenblatt

The Effect of Ritonavir and Chronic Viral Hepatitis on Cytochrome 3A Activity in HIV Infected Patients

Oleson, Knox, von Moltke, Kaufman, Greenblatt

Sleep Duration and Overweight in Early Elementary School Children

Hennessy, Kuder, Goldberg, Must, Sacheck, Economos

Children’s Multiple Representation of Their Ideas about Science


Transforming Science Learning in the Elementary Grades Through LEGO™ Engineering Design

Jarvin, Rogers, Bethke Wendell, Wright

The Child and Adolescent Scale of Participation (CASP): Further Psychometric Testing


Translating Community-Based Asthma Research in Boston Chinatown into a Community-Based Program

Palella, Chin, Lane, Brugge

A Model for Clinical Evaluation of Perioperative Analgesia in the Rabbit

Karas, Weaver, Andrutis, Blaze

Bioinformatics Identifies 107 Candidate Transcription Factors Involved in Fat Storage

Lane, Parnell, Ordovas

Central Dopamine Deficits as Markers for Dietary Obesity Predisposition

Geiger, Frank, Caldera-Siu, Beinfeld, Pothos

Exposure to Low Frequency Magnetic Fields Alters Catecholamine Exocytosis

Saveriades, Dunlap, Theoharides, Sergiadis, Pothos

Chronic Morphine Exposure in Peripubertal Female Rats Results in Altered Opioid Sensitivity and Tolerance in Their Offspring

E. Byrnes, Babb, Scanlan, J. Byrnes

Cell Cycle Re-entry and the Role of Molecular Chaperones in β-Amyloid Laden Skeletal Muscle Cells and Alzheimer’s Disease Brain

Kumar, Fu, Lee, Querfurth

Changes in Expression and Chromatin Structure of the Mental Retardation Gene Jarid1c in Neural Differentiation

Xu, Arnold , Disteche

Assessment of Sleep Disorders in Patients with Chronic Orofacial Pain

Lobo Lobo, Chandwani, Kulich, Mehta, Scrivani

Gold Nanocatalysts for Clean Energy Production

Flytzani-Stephanopoulos, Deng, Si, Zhai

Detection of Biomolecules by Magnetic Reporting of Magnetically Labeled Nanorods

Harrah, Xie, Oh, Naughton, Sun, Guertin, Goldberg

Experimental Techniques for Understanding Chemical Mechanical Polishing

Gray, Vlahakis, Braun, Rogers, Manno

Reproductive Experience Increases Neural Prolactin Receptor and Socs-1 and -3 mRNA Expression in the Rostral Hypothalamus of Female Rats

Bridges, Anderson,
van der Ancker, Grattan

Arginine Vasopressin Antagonism Affects Maternal Aggression and the Retention of Maternal Behavior in Lactating Rats

Nephew and Bridges

The Mechanical Properties of Caterpillar Cuticle

Lin, Dorfmann, Trimmer

Occipitocervical Fusion in a Dog Using Locking Buttress Plate Fixation and Synthetic Bone Graft (rhBMP-2 CRM)

Boudrieau and Faissler

Predictors of Mobility-Disability in Older Adults: The Role of Lower Extremity Muscle Strength and Body Composition

Reid, Naumova, Carabello, Phillips, Frontera, Fielding

Slow Rate of Neuromuscular Activation Contributes to Impaired Movement Acceleration and Peak Power in Mobility-Limited Older Adults

Clark, Patten, Reid, Carabello, Phillips, Fielding

Effect of Almond Skin Polyphenols and Quercetin on Human LDL and Apolipoprotein B-100 Oxidation and Conformation

Chen and Blumberg

Almond Consumption Reduces Oxidative DNA Damage and Lipid Peroxidation in Male Smokers

Chen, Jia, Li, Blumberg

Rock1, Rock2 and a Little Rock: Can a Little Gene Make the Difference?

Montefusco, Wooten, Huggins