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This event focused on Tufts' strength in cancer research, with talks delivered by Sergio Fantini, Charlotte Kuperwasser, and Richard Van Etten, as well as lightning talks and poster presentations.

Friday, October 17, 2008

Jean Mayer USDA Human Nutrition Research Center on Aging
711 Washington Street
Boston, MA 02111

Lightning Talks

Richard Wein, Chieko Azuma, Catherine Freudenreich
Krishna Kumar, Amy Yee, Rong Shao
New Targets
Al Charest, Philip Hinds, Brigitte Huber
Emerging Technologies
Daniel Jay, Jonathan Garlick, Eric Miller

Research Presentations 

Insights into the Pathogenesis and Therapy of Human Leukemia through Studies in Mice
Richard Van Etten
Elucidating the Origins of Human Breast Cancer Heterogeneity
Charlotte Kuperwasser
Optical Mammography: Using Light to Detect Breast Cancer
Sergio Fantini
Jean Mayer USDA Human Nutrition Research Center on Aging Auditorium
Poster Presentations and Reception 
Jean Mayer USDA Human Nutrition Research Center on Aging Lobby, Mezzanine and Conference Room


Moderated by Amy Yee 

Risk Factors in the Development of Nasopharyngeal Carcinoma
Richard Wein
Mapping Genes Associated with Spontaneous Canine Hemangioma and Expression Profiling: Potential Animal Model for Human Angiosarcoma
Chieko Azuma
Chromosomal Fragile Sites: Why They Break and the Cancer Connection
Catherine Freudenreich


Moderated by Catherine Freudenreich 

Novel Carbohydrate Based Cancer Therapeutics and Imaging Agents
Krishna Kumar
The HBP1 Transcriptional Repressor and Invasive Breast Cancer Mechanisms
Amy Yee
A Cancer Biomarker YKL-40 Induces Tumor Angiogenesis
Rong Shao

New Targets

Moderated by Jonathan Garlick

Genetic Dissection of EGFR Signaling Networks in Glioblastoma
Al Charest
Cdk Inactivation Targets Tumor Initiating Cells
Philip Hinds
Dipeptidyl Peptidase 2 as a Novel Prognostic Factor and Therapeutic Target in Chronic Lymphocytic Leukemia
Brigitte Huber

Emerging Technologies

Moderated by Philip Hinds

Light Inactivation Screen for Surface Proteins Required in Cancer Cell Invasion
Daniel Jay
Engineered 3D, Human Tissue Platforms: Meeting the Needs of the Translational Pipeline in Cancer Discovery
Jonathan Garlick
Ultrasound-based Guidance of HIFU Cancer Treatment
Eric Miller

Sergio Fantini, PhD
Sergio Fantini, PhDProfessor of Biomedical Engineering and Associate Dean for Graduate Education in the School of Engineering at Tufts University. Professor Fantini’s research focus is in the area of biomedical optics, specifically in diffuse near-infrared spectroscopy and the imaging of biological tissues. His research laboratory has ongoing projects aimed at the noninvasive, functional imaging of the brain, the study of optical signatures of peripheral nerve activation, and the development of novel instrumentation for optical mammography. Professor Fantini’s lab has developed a novel approach to spectral imaging of the human breast that shows promise for the detection, diagnosis, and monitoring of breast cancer.
 Charlotte Kuperwasser, PhD 
Charlotte Kuperwasser, PhDAssistant Professor in the Department of Anatomy and Cellular Biology at Tufts University School of Medicine; investigator at the Molecular Oncology Research Institute, Tufts Medical Center. Dr. Kuperwasser’s lab works on breast cancer, with interests in the cellular origins of tumor formation, cancer progression, and metastasis. Dr. Kuperwasser has been working toward an understanding of the role of the tissue microenvironment in breast cancer metastasis and has developed a humanized animal model to identify cellular elements in the bone stroma (cell types, growth factors, matrix proteins) that promote tumor formation in sites distant from the primary tumor.
Richard Van Etten, PhD 
Richard Van Etten, PhDProfessor of Medicine, Tufts University School of Medicine; Chief, Division of Hematology/ Oncology, Tufts Medical Center; Interim Director, Tufts Medical Center Cancer Center. Dr. Van Etten’s laboratory studies the molecular pathogenesis of human leukemia. The Van Etten lab uses retroviral and transgenic technology to produce accurate and faithful mouse models of leukemia that can be used to identify and evaluate new treatment approaches. Their work was instrumental in identifying the BCR-ABL enzyme as the direct cause of chronic myeloid leukemia (CML). They subsequently identified one of the first ABL mutations that causes resistance to the anti-CML drug imatinib (Gleevec) and are currently testing new treatments for patients with drug-resistant CML.


Is the Mammary Stroma of Copenhagen Rats a Tumor Suppressor?


Drexler, Schaeberle, Maffini

Stromal Influences on the MCF7 Cells Phenotype in 3-Dimensional Cultures


Krause, Maffini, Soto, Sonnenschein

In Utero Exposure to Bisphenol A: Links with Mammary Gland Cancer Development


Murray, Maffini, Sonnenschein, Soto

Parity Alters Responses to Ionizing Radiation in the Mammary Gland


Carter, Troester, Johnson, Jerry, Smith Schneider

Defining the Cellular Origins of Human Breast Cancer Heterogeneity


Keller, Klebba, Gupta, Gilmore, Schnitt, Kuperwasser

Morphology and Proliferation Control of Normal and Malignant Breast Epithelial Cells in a Collagen-Based 3-Dimensional Model of Tissue Microenvironment


Dhimolea, Maffini, Soto, Sonnenschein

Knockdown of Spry2 by RNA Interference in Human Mammary Epithelial Cells Results in Increased Cell Cycle Progression and Migration


Friesel, Toher, Liaw

The Wnt/β-Catenin Signaling Antagonist, SFRP1, Directly Affects the Tumorigenic Properties of Non-Malignant and Malignant Mammary Epithelial Cells


Gauger, Hugh, Ostrander,
Smith Schneider

Elucidating the Role of Wnt Signaling in Breast Cancer


DiMeo, Anderson, Naber, Kuperwasser

Inhibitory Effects of Rhodiola Crenulata on an Invasive Immortal Human Cell Line


Rodríguez-Cortés, Gauger, Smith Schneider

Tumor-Targeted Delivery of TRAIL Using Salmonella TyphimuriumEnhances Breast Cancer Survival


Ganai, Arenas, Forbes

Disease Modeling and Tissue Engineering: Breast Cancer Metastasis to Bone


Reagan, Goldstein, Rosenblatt, Kaplan

A Humanized Model of Breast Cancer Metastasis Revealing a Human-Specific Metastasis Gene Signature


Goldstein, Anderson, Rosenblatt

Role of Bone Sialoprotein (BSP) Overexpression in Osteolytic Metastasis in CMV-BSP Transgenic Mice


Tu, Chen, Jang, Kim

Targeted Overexpression of BSP in Osteoclasts Promotes Bone Metastasis of Breast Cancer


Tu, Fix, Tang, Zhang, Chen

Treating Ductal Carcinoma in Situ (DCIS) of the Breast with Tamoxifen: A Decision Analysis of the Risks and Benefits of Warfarin Anticoagulation in a Patient at Increased Risk for Thromboembolism


Evans, Wong, Pauker

Determining the Role of Immune System Function in Breast Cancer Using an Imagable Syngeneic Model of Breast Cancer


Fang, Tao, Sahagian

Molecular Basis for Intravasation and Metastasis to Lung Using an Orthotopic Mouse Model of Breast Cancer


Fang, Tao, Sahagian

Use of a Standardized Web-Based Tool for Evaluation of Bone Health in Breast Cancer Patients


Arnaoutakis, Wong, Parameswaran

Progenitor-Progeny Relationships of the Marker Defined Cell Subsets in the Human Prostate


Makarovskiy, Geck, Parmelee, Tai, Carpinito

New Target Genes in Prostate and Breast Cancer: Methylation and MicroRNA Silencing of a Stem Cell Differentiation Gene, APRIN, in Clinical Studies


Pilichowska, Denes, Kim, Makarovskiy, Carpinito, Geck

β1 Integrin Participates in Endoglin-Dependent Inhibition of Prostate Cancer Cell Migration


Romero, Roth, Brooks, Vary

PVR/Necl-5 Promotes Glioblastoma Invasion by Activation of the Akt Pathway and MMP-2 Production


Enloe and Jay

Role of Histone H3K27 Demethylases in Maintenance of Multipotency in Glioblastoma Stem Cells


Sherry, Reeves, Wu, Cochran

A Conditional RNAi Strategy to Investigate Signaling Networks in Glioblastoma Multiforme


Acquaviva, Ramachandran, Woolfenden, Charest

Somatostatin Therapy for Recurrent Meningiomas


Kandil, Zhu, Heilman, Wu

Clinical Impact of Adjuvant Gamma Knife Radiosurgery to the Surgical Cavity of Resected Metastases: A Retrospective Review of the Tufts Medical Center Experience


Hwang, Eisenberg, Hale, Dvorak, Boskovitz, Yao, Pfannl, Mignano, Zhu, Strauss, Wu

Improvement of Neurological Function after Concurrent Treatment IVIG and Chemotherapy in a Patient with Cerebellar Degeneration Paraneoplastic Syndrome


Zhu, Li, Hedges, Wakeley

Larger Lentigo Maligna Lesions and Invasive Melanoma: Size Matters


Zeikus, Kakullavarrupu, Olbricht

Mapping Genes Associated with Spontaneous Canine Hemangiosarcoma and Expression Profiling, Potential Animal Model for Human Angiosarcoma


Karlsson, Tonomura, Barber, Burgess, Shaw, Keating, Meola, Xu

YKL-40 Demonstrates a Protective Role in Rhabdomyosarcoma by Decreasing MMP-2


Scully, Yan, Shao

MicroRNA Expression Profiling: Connecting Lung Development and Lung Cancer


Mujahid, Volpe, Nielsen

Fibroblasts Affect the Phenotype of Normal Human Bronchial Epithelial Cells when Co-Cultured in Three-Dimensional (3D) Organotypic Cultures


Pageau, Maffini, Soto, Sonnenschein

Laser Capture Microdissection to Isolate Primary and Metastatic Thyroid Tumors from Formalin Fixed Paraffin Embedded Tissue


Kim and Cheng

Mrc1 and Tof1 Participate in the Maintenance of CAG•CTG Repeat Tract Integrity


Gellon, Lahiri, La Porte, Freudenreich

The Importance of Spatial Distribution of Stemness and Proliferation State in Determining Tumor Radio-Response


Enderling, Park, Hlatky,

The Yin and Yang of ERK Regulation by Polyomavirus Middle T (MT)


Zhu and Schaffhausen

Solution Structure of the Hdlg/SAP97 PDZ2 Domain and its Mechanism for Interaction with HPV-18 E6 Protein


Liu, Henry, Hegde, Baleja

Scaffold Proteins Regulate Localized Rac Activation by Tiam1


Rajagopal, Li, Wicks, Wong, Isberg, Buchsbaum

Sequence-Specific Chromatin Remodeling of the C-Myc Promoter by hSWI/SNF


Sims, Baughman, Lane, Schnitzler

Inhibition of CBF-1-Mediated Notch Signaling Induces FGF-Dependent Transformed Cell Phenotype


Kacer, McIntire, Kirov, Prudovsky

Investigating Cancer Progression of Cells in 3D Matrix with Non-Invasive Fluorescent Imaging


Xylas, Alt-Holland, Garlick, Georgakoudi

Cancer Cells Modulate DNA DSB/Repair in Nontransformed Cells


Beheshti, Enderling, Perkins, Burg, Hahnfeldt, Hlatky

Antiangiogenic Effects of Proton Irradiation


Girdhani, Hahnfeldt, Beheshti, Anaya, Peluso, Lamont, Raychowdhury, Schwager, Huber, Enderling, Abdollahi, Hlatky

Impaired Angiogenesis in Aged Tumor Microenvironment Attenuates Tumor Growth


Kalinga, Beheshti, Hahnfeldt, Abdollahi, Hlatky

Neuregulin-1 Alleviated Doxorubicin-Induced Down-Regulation of Cardiac Troponin Proteins in the Heart


Bian, Sun, Silver, Ho, Marchionni, Caggiano, Morgan, Yan

Evaluating the Efficacy of Stereotactic Spinal Radiosurgery


Yao and Bakes

Selective Inhibition of Growth of Tuberous Sclerosis Complex 2-Null Cells by Atorvastatin is Associated with Impaired Rheb and Rho Gtpase Function and Reduced Mtor/S6 Kinase Activity


Finlay, Malhowski, Liu, Fanburg, Kwiatkowski, Toksoz

Genetic Variants in Uracil Processing Enzymes are Associated with Abnormal DNA Uracil Content


Chanson, Parnell, Crott, Choi, Han, Mason

Dipeptidyl Peptidase 2 is a Novel Prognostic Factor and Therapeutic Target in Chronic Lymphocytic Leukemia


Danilov, Danilova, Klein, Brown, Rabinowitz, Miller, Huber

Distinct Gab2-Mediated Signaling Pathways are Essential for Myeloid or Lymphoid Transformation and Leukemogenesis by BCR-ABL


Chan, Mohi, Li, Neel, Van Etten

Environmental Risk Factors and Risk of Canine Malignant Lymphoma: A Model for Human Non-Hodgkin’s Lymphoma


Zagarins, Barber, Procter-Gray, Gollenberg, Bertone-Johnson

Comparative Oncology Trials Consortium Aids in Development of Human Cancer Therapies


Barber, Burgess, Marshall

GS-9219 – A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non-Hodgkin’s Lymphoma


Burgess, Vail, Thamm, Hawkins, Tumas

Tissue Banking at the Cummings School as Part of the Canine Comparative Oncology Genetics Consortium


Burgess, Barber, Azuma, Marshall, Meola, Berg

Novel, 3D Human Tissue Platforms for Cancer Discovery: The Core for Experimentation in 3D Tissues


Garlick and Egles

Tufts Medical Center Transgenic Core Facility


Rwayitare, Riggs, Mendelsohn, Lem

Tufts Animal Pathology and Histology Core Laboratory Services


Richey, Lagace, Papalegis

Proteomic Research and Services of the Tufts Proteomic Core Facility



Getting Your Research Done with University Information Technology (UIT) Services



Light Scattering Spectroscopic Characterization of Healthy and Cancerous White Blood Cells



Hyperspectral Image Reconstruction for Diffuse Optical Tomography



Avenanthramides Inhibit Proliferation of Human Colon Cancer Cell Lines in vitro


Guo, Nie, Wu, Wise, Collins, S. Meydani, M. Meydani

A Novel Mouse Model for Sporadic Colorectal Cancer


Hung, Maricevich, Georgeon Richard, Kunin, Kho, Mahmood, Kucherlapati

Nonalcoholic Steatohepatitis Induced by a High-Fat Diet Promotes Diethylnitrosamine Initiated Early Hepatocarcinogenesis in Rats


Wang, Ausman, Greenberg, Russell, Wang

Nasopharyngeal Carcinoma at Tufts Medical Center: Evaluation of the Chinatown and Greater Boston Incidence and Response to Treatment


Wein and Merdad

Dose De-Escaltion with Gamma Knife Radiosurgery in the Treatment of Choroidal Melanoma


Mignano, Chan, Schirmer, Melhus, Williams, Do-Dai, Duker, Yao

Molecular Characterization of EBV Associated Nasopharygeal Carcinoma


Merritt and Thorley-Lawson

Frequency of Presentation and Risk Profile for Human Papillomavirus in Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma at Tufts Medical Center


Kraus, Oreadi, Wein, Laver, Papageorge

RalA Suppresses Invasion by Ras-Transformed Keratinocytes in a Bioengineered Human Tissue Model of Squamous Cell Carcinoma


Sowalsky, Alt-Holland, Shamis, Garlick, Feig

The Tumor Microenvironment Meets Epigenetics: Regulation of E-Cadherin Expression in Squamous Cell Carcinoma Progression through DNA Methylation


DesRochers, Kudo, Takata, Garlick

Loss of E-Cadherin-Mediated Cell-Cell Adhesion Induces the Transition from Precancer to Squamous Cell Carcinoma through Activation of FAK and Src Kinases


Alt-Holland, Szwec-Levine, Green, Garlick
Quality of Life in Patients with Resected and Reconstructed MandiblesOreadi, Shastri, Chapman, Papageorge