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Notice of Special Interest (NOSI): Administrative Supplement for Continuity of Biomedical and Behavioral Research Among First-Time Recipients of NIH Research Project Grant Awards. The overarching goal of this pilot program is to enhance the retention of investigators facing critical life events who are transitioning to the first renewal of their first independent research project grant award or to a second new NIH research project grant award. This program supports “at-risk” investigators as identified in the NIH Next Generation Researchers Initiative (see https://grants.nih.gov/ngri.htm). This retention program seeks to maintain the productivity of current first-time recipients of eligible independent NIH research project grant awards who are dealing with a critical life event(s), such that they can remain competitive for the first renewal of their award or for a second research project grant award. For retention supplements to support the transition from K award to independence, see the companion NOSI. PD/PIs of the following activity codes are eligible for the program: DP1DP2DP5R01R00,  R15, R21R35RF1, and U01and who have a qualifying critical life event. PD/PIs with more than one independent research project grant award are ineligible for this supplement. Supplement requests must be submitted in accordance with the parent program announcement: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) PA-18-591or its subsequent reissued equivalent. First Available Due Date: March 05, 2020