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Fluctuations in mental status occur commonly in dementia. Such fluctuations vary by dementia type and are most apparent in earlier stages of disease. However, even in late-stage dementia, patients have been reported to exhibit unexpected episodes of mental clarity or lucidity, characterized by spontaneous meaningful and relevant communication at a time when the capacity for coherent speech has presumably been lost. These FOAs are intended to advance scientific understanding of lucidity in dementia by supporting an initial set of retrospective and/or prospective studies that will lay the groundwork for further research on this topic.

Lucidity in Dementia (R21 Clinical Trial Optional) (RFA-AG-20-016) Studies supported by this FOA will use the R21 mechanism to support initial exploratory/developmental aims that will serve as the foundation for future studies.

Lucidity in Dementia (R21/R33 Clinical Trial Optional) (RFA-AG-20-017) Studies supported by this FOA will use the R21/R33 phased innovation mechanism to support initial exploratory/developmental aims during the R21 phase followed by further expanded aims during the R33 phase.

Application Due Date(s): February 3, 2020