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Functional RNA Modifications Environment and Disease (FRAMED) (R21 Clinical Trial Not Allowed)

RFA-ES-19-002R21 Exploratory/Developmental Grant

Funding Opportunity Purpose

Chemical modifications of proteins, DNA and RNA nucleoside moieties play critical roles in regulating gene expression.  Emerging evidence suggests these RNA modifications (epitranscriptomics) have substantive roles in basic biological processes. Recent studies in yeast, Drosophila and rodent models demonstrate stressors can induce RNA modifications, with specific epitranscriptomic reprogramming of some regulatory RNAs.  The purpose of the Functional RNA Modifications Environment and Disease (FRAMED) FOA is to solicit and support R21 applications that propose innovative, high risk, high reward research addressing how environmental exposures impact this layer of cellular regulation.

Application Due Date: May 16, 2019