Through this FOA, the NCI invites cooperative agreement (U2C) applications for HTA Research Centers, a collaborative research initiative that aims to build tumor atlases through the dynamic multiparameter characterizations of cancerous lesions across high-priority cancer types, including those that disproportionally effect minority and underserved patients. The HTA Research Centers will each lead construction of at least one, but no more than three, organ-specific human tumor atlases that describe overall cellular and molecular architecture of critical transitions in tumorigenesis for use by the research and clinical communities.
Through this FOA, the NCI invites applications for the PCA Research Centers, a collaborative research initiative that aims to construct comprehensive, dynamic, high-resolution, multidimensional, multiparametric, temporal and scalable atlases of pre-cancerous lesions and their surrounding microenvironment for select organ sites, including high-priority cancers that disproportionally affect minority and underserved patients. A deeper understanding of the transition from pre-malignant to malignant state as a function of time will allow the development of more precise risk stratification methods and effective early intervention strategies. Each PCA Research Center will lead the construction of at least one human pre-cancer atlas for use by the research and clinical communities.
Human Tumor Atlas Network: Data Coordinating Center (U24)
Through this FOA, the NCI invites cooperative agreement applications to develop a Human Tumor Atlas Network (HTAN) Data Coordinating Center (DCC). The HTAN-DCC will have two major areas of responsibility: (1) Data Standards, Storage, Analysis, and Dissemination; and, (2) Consortium Coordination and Outreach. The HTAN-DCC will collect, store, curate, and disseminate all data, metadata, analysis and visualization tools, computational models, and completed atlases generated by the HTAN. Additionally, the DCC will lead the development of common data elements, data and metadata standards, clinical and epidemiological data requirements, and data processing pipelines. The DCC will also coordinate HTAN activities including in-person and virtual Network Steering Committee meetings and working groups. Finally, the HTAN-DCC will promote collaboration and communication among HTAN Investigators and the broader research community and coordinate the Network outreach activities.