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Approval Date: June 5, 2019

Background: Federal regulation, Public Health Service (PHS) Policy, and standards of AAALAC accreditation require that each research institution establish a process for management and oversight of animal care and use activities. The primary person that holds this responsibility for each animal care and use protocol is the Principal Investigator (PI).

Institutional Responsibility: It is the responsibility of the Principal Investigator to ensure that all animal work is performed in compliance with all relevant regulations and institutional policies.

Policy: Principal Investigator eligibility for a Contract or Grant is separate from Principal Investigator eligibility for research, teaching, or training using animal subjects. Listed below are the criteria required in order to be a Principal Investigator on an IACUC animal protocol.

  1. Tufts University or Tufts Medical Center employee or an external person with a contractual relationship with the Institution.
  2. Terminal degree at the level of PhD, MD, D.Sc., DDS, DVM/VMD, or equivalent.

NOTE: The IACUC recognizes that there may be situations where the appropriate Principal Investigator for an animal protocol does not hold one of these requirements. In these cases, the role of PI will be reviewed and approved by the IACUC on an individual basis. Additional information may be requested from the proposed PI.

Principal Investigator Responsibilities: The Principal Investigator is responsible for authorizing and affirming the following under all Tufts University/Tufts Medical Center Animal Care and Use Protocols.

  • The information contained in this protocol is true and accurate, and to the best of my knowledge conforms to Tufts University/Tufts Medical Center IACUC, NIH, USDA, and MDPH policies on the use of animals in research and teaching.
  • I have considered alternatives to the biological models used in this project and have found these other methods unacceptable on scientific or educational grounds.
  • I certify that I have determined that the research proposed herein is not unnecessarily duplicative of previously reported research.
  • I accept responsibility for ensuring that all personnel involved in this project will be trained regarding any potential biological, chemical, and radiological hazards, relevant safety practices, and emergency procedures. If applicable, I confirm that all relevant institutional regulatory requirements (e.g. Chemical Safety Plan, IBC Registration, Radioactive Materials Permit, etc.) will be followed.
  • I will complete all IACUC personnel requirements, as described in the Policy on Requirements for Personnel Working with IACUC-Covered Animals prior to working with animals OR within 2 months of the approval of my protocol, whichever comes first.
  • All personnel involved in this project will be added to the protocol using a Supplement P. All personnel involved will agree to participate in the study and will be aware of the approved procedures by reading the approved protocol and amendments. All individuals involved will be instructed in the humane care, handling, and use of animals, and I will review their qualifications. I will properly train all individuals performing euthanasia and will maintain training records as required in the IACUC Policy on Euthanasia.
  • No change will be made to procedures, care or housing without prior written notification to and approval by the Institutional Animal Care and Use Committee (IACUC).
  • I understand that it is non-compliant to release an IACUC approval date without documentation of a congruency comparison conducted by the IACUC Office. For more information, please see the Policy on Requiring a Congruency Comparison Prior to Release of IACUC Approval Dates.
  • I accept responsibility for complying with Material Transfer Agreement requirements. For more information, please see Material Transfer guidance on the Tufts Tech Transfer website.
  • I understand that failure to comply with IACUC policies and procedures will jeopardize Tufts University’s or Tufts University-Tufts Medical Center’s Animal Welfare Assurances on file with the NIH, and may lead to revocation of my privileges to conduct animal research at this institution.

Principal Investigator Signatures: An electronic signature and/or email documentation from the Principal Investigator is considered a valid signature.

Change in Principal Investigator Status: An amendment for a “Change in PI” must be submitted using the Full Committee Review or Expedited Review processes. See “IACUC Policy on Review Procedures and Voting Categories”. All required training must be in place before an individual can assume the role of PI on an IACUC protocol.