This event showcased the University’s newest enterprise, the Tufts Institute for Innovation (TII). It introduced the TII initiative and hopes to engage the Tufts community in helping to shape its priorities and direction.

Friday, September 20, 2013

Tufts School of Dental Medicine
1 Kneeland Street
Boston, MA 02111

 

TII: Overview, Challenges, and Opportunities

David Walt, Robinson Professor of Chemistry, Howard Hughes Medical Institute Professor, School of Arts & Sciences
 

Defining Innovation at Tufts Institute for Innovation

Bhaskar Chakravorti, Senior Associate Dean for International Business and Finance, Executive Director of the Institute for Business in the Global Context and the Center for Emerging Markets Enterprise, The Fletcher School
 

Question and Answer Session

David Walt and Bhaskar Chakravorti
 

Lightning Talks

Molecular Strategies to Impact Microbial Disease
Joshua Kritzer
Living Materials
Fiorenzo Omenetto
Nutrition and Infection: Understanding the Linkages
Christine Wanke
The Environment and Microbes
Kurt Pennell
 

Breakout Session I

Molecular Strategies to Impact Microbial Disease 
Emerging Platforms and Technologies to Study Microbes and Therapeutic Delivery
Fighting Microbes: From Bench to Bedside to Worldwide
The Environment and Microbes
 

Lightning Talks

Microbes and Infectious Disease
John Leong
The Microbiome – Understanding the Microbiome for Health Benefits
Andrew Greenberg
The Application of New Technologies in Vaccinology, Therapeutics and Delivery Platforms
Chuck Shoemaker
Informatics and Data Analysis to Study Microbes and Their Impacts
Carla Brodley
 

Breakout Session II

Microbes and Infectious Disease
Studying the Microbiome and Its Impact
The Human Condition and Microbes
Informatics Approaches to Studying the Impact of Microbes
 

Lighting Talks

Economic Strategies for Sustainable Health
Shinsuke Tanaka
Environmental Epidemiology, Infectious Diseases and Global Health
Elena Naumova

Molecular Strategies to Impact Microbial Disease
Joshua Kritzer, Assistant Professor of Chemistry, School of Arts and Sciences
 
Living Materials
Fiorenzo Omenetto, Frank C. Doble Professor of Engineering, School of Engineering
 
Nutrition and Infection: Understanding the Linkages
Christine Wanke, Director of the Nutrition Infection Unit, Associate Chair of the Department of Public Health and Community Medicine, Professor of Medicine & Public Health and Community Medicine, School of Medicine
 
The Environment and Microbes
Kurt Pennell, Professor & Chair of Civil and Environmental Engineering, School of Engineering
 
Microbes and Infectious Disease
John Leong, Professor & Chair of Molecular Biology and Microbiology, School of Medicine
 
The Microbiome – Understanding the Microbiome for Health Benefits
Andrew Greenberg, Senior Scientist & Director of Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging
 
The Application of New Technologies in Vaccinology, Therapeutics and Delivery Platforms
Chuck Shoemaker, Professor of Infectious Disease and Global Health, Cummings School of Veterinary Medicine
 
Informatics and Data Analysis to Study Microbes and Their Impacts
Carla Brodley, Professor of Computer Science, School of Engineering
 
Economic Strategies for Sustainable Health
Shinsuke Tanaka, Assistant Professor of Economics, The Fletcher School
 
Environmental Epidemiology, Infectious Diseases and Global Health
Elena Naumova, Associate Dean for Research, Professor of Civil and Environmental Engineering, School of Engineering, Professor of Public Health and Family Medicine, School of Medicine

Breakout Session I

Molecular Strategies to Impact Microbial Disease
Inflammation and host response, pathogenesis, immunology, synthetic biology, bacterial metabolism, synthetic biology, synthetic chemistry, inflammation and host response, immunology, pathogenesis, molecular work to characterize microbe function and identification of molecular targets.
Facilitator:
Krishna Kumar, Professor and Chair of Chemistry, School of Arts and Sciences
 
Emerging Platforms and Technologies to Study Microbes and Therapeutic Delivery
Metagenomics, synthetic chemistry, health informatics tools, analytical methods for microbe detection and diagnosis of infection, biosensor technologies, drug delivery devices, micro and nanotechnology for vaccine delivery and engineering approaches to reduce transmission of infectious disease.
Facilitator:
Qiaobing Xu, Assistant Professor of Biomedical Engineering, School of Engineering
 
Fighting Microbes: From Bench to Bedside to Worldwide
Approaches to anti-infective therapy, microbial disease prevention, chemical biology/microbiology, planning to treat emerging pandemics, and cancer, microbial disease in pediatric populations, managing infectious disease in the aged, clinical approaches to microbial resistance.
Facilitator:
Jonathan Garlick, Professor of Oral Pathology, School of Dental Medicine Professor, School of Medicine; Professor of Biomedical Engineering, School of Engineering
 
The Environment and Microbes
Environmental microbiology, geologic/soil/groundwater microbiology, intersection of the human-microbial-animal worlds, impact on water systems, ecosystems, wildlife and conservation medicine, microbial evolution, bioremediation, microbes and climate change and their impact on climate justice.
Facilitator:
Kurt Pennell, Professor and Chair of Civil and Environmental Engineering, School of Engineering
David Gute, Associate Professor of Civil and Environmental Engineering, School of Engineering

Breakout Session II

Microbes and Infectious Disease
Chemical biology/microbiology, emerging threats (pandemics), drug and vaccine discovery, public health, epidemiology, prevention, chemical biology/microbiology, obesity and the microbiota, infectious agents and cancer, viral pathogenesis of human disease, antibiotic resistance.
Facilitators:
Ralph Isberg, Professor of Molecular Biology and Microbiology, School of Medicine
Sam Telford, Professor of Vector-Borne Infections, Infectious Disease and Global Health Medicine, Cummings School of Veterinary Medicine
 
Studying the Microbiome and Its Impact
Metabolite analysis, animal models of infectious disease, global DNA sequencing and bioinformatics, changes in microbial flora under stress conditions and nutritional states, impact of the microbiome on disease states, microbes as therapeutics, microbes for nutritional benefits, the microbiome and cognition, impact of the microbiome on organ/tissue-specific niches.
Facilitators:
Honorine Ward, Professor of Medicine, Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Professor of Public Health and Family Medicine, School of Medicine
Gillian Beamer, Assistant Professor of Infectious Disease and Global Health, Cummings School of Veterinary Medicine
 
The Human Condition and Microbes
Policy and regulation to distribute to global populations, business model design, monitoring systems in developing countries, health care, financial services, access to arts/aesthetics, sustainable demographic interventions, connect emerging science to the “market”, impact on urbanization, innovation models, market “disruption”, economic strategies for better health, economic findings relevant to improving access to healthcare in developing countries, demand-side challenges leading to suboptimal health investments, supply-side issues in healthcare delivery, ethical concerns in therapy development and delivery, infectious disease links to health disparities and vulnerable populations.
Facilitator:
John Morgan, Dentist in Chief/Administrative Director, School of Dental Medicine
 
Informatics Approaches to Studying the Impact of Microbes
Informatics, modeling, metabolite analysis, animal models of infectious disease, global RNA and protein analysis, computational epidemiology, environmental indicators of infectious diseases, climate and weather and informatics, public health applications of infectious disease modeling, systems approaches to studying the impact of infection on the host, bioinformatics approaches for microbiome analysis, tools, statistical approaches and methodologies to handle big data.
Facilitator:
Lakshmanan “Lax” Iyer, Research Assistant Professor of Neuroscience, School of Medicine

TitleAuthor(s)

Menaquinones Content of Human Serum and Feces

 

Karl, Fu, Saltzman, Meydani, Meydani, Barnett, Booth

Differential Cellular Uptake and Metabolism of Curcuminoids in Monocytes/Macrophages: A Possible Mechanism of Differential Effects of Curcuminoids on Lipid Uptake and Bacterial Phagocytosis

 

Nakagawa, Zingg, Kim, Thomas, Dolnikowski, Azzi, Miyazawa, Meydani

Modulation of CD36 Scavenger Receptor Expression by Curcumin and Vitamin E Affects Cellular Uptake of Lipids and Bacteria

 

Zingg, Nakagawa, Azzi, Meydani

The Interaction between the Intestinal Microbiome and the Enteric Pathogen Cryptosporidium parvum

 

Ras, Tzipori, Widmer

Identification, Quantification, and Characterization of Microbiota Metabolites in Murine Gut using In Silico Analysis and Targeted Metabolomics

 

Sridharan, Choi, Wu, Klemashevich, Prabakaran, Pan, Alaniz, Jayaraman, Lee

IL-17A-Mediated Protection in Acanthamoeba-Induced Keratitis

 

Suryawanshi, Cao, Noorjahan Panjwani

Galectin-1-Mediated Suppression of Pseudomonas aeruginosa-Induced Corneal Immunopathology

 

Suryawanshi, Cao, Panjwani

The New England Regional Biosafety Laboratory – A Regional BSL3 Facility at TCSVM

 

Akiyoshi and Tzipori

Novel Bisphosphocin Nu3 Demonstrates Rapid in vitro Killing of Bacteria-Encased in Biofilm

 

Akiyoshi, Dilo, Marshall, Levy, DiTullio

Translating Science into Global Ecosystem Health: Establishment of the Department of Infectious Disease and Global Health at the Cummings School of Veterinary Medicine

 

Akiyoshi, Amuguni, Ellis, Beamer, Da’darah, Fenwick, Krautz-Peterson, Lee, Lindenmayer, Muhkerjee, Murray, Nutter, Pokras, Robbins, Saila-Ngita, Sheoran, Shoemaker, Skelly, Steele, Sun, Telford, Tseng, Whittier, Widmer, Tzipori

Yersinia Interactions with Innate Immune Cells in Different Organ Tissues

 

Paczosa, Green, Murphy, Maldonado-Arocho, Garcia-Rolan, Mecsas

Endosymbiotic Bacteria of Shipworms (Bivalvia: Teredinidae) Secrete Compounds with Anti-Parasitic Activity

 

O’Connor, Distel, Elshahawai, Haygood

The Role of Environmental Parameters in Characterizing Exposure to Enteric Pathogens in Urban and Rural Settings in South India

 

Kulinkina, Balraj, Raghava, Naumova

Bioremediation of Contaminated Aquifers: Engineering Approaches to Facilitate the Degradation of Toxic Pollutants to Benign By-Products Using Subsurface Microorganisms

 

Marcet, Meade, Pennell, Cápiro

Accuracy and Usability of Free Chlorine Residual Testing Methods

 

Murray and Lantagne

CD209a Expression on Dendritic Cells is Critical for the Development of Pathogenic Th17 Cell Responses in Murine Schistosomiasis

 

Ponichtera, Shainheit, Larkin, Raychowdhury, Russo, Salantes, Bunnell, Hacohen, Stadecker

Generation of D-peptide Antibiotics via Mirror-Image Phage Display

 

Adaligil, Patil, Kumar

CD4-CD8- T cells, B cells and Complement are Critical for Resolution of Babesia microti Infection in the Absence of CD4

 

Leveque, Silver, Wilson, Su, Telford, Gelfand, Wortis, Krause, Vannier

Gluma Antimicrobial Effect on Five Strains of Cariogenic Bacteria

 

Bui, Klein, Perry

An Adenovirus Vector Expressing a Single VHH-Based Neutralizing Agent (VNA) Protects Piglets from Fatal Systemic Complications Induced by Infection with Shiga Toxin Producing E. coli

 

Sheoran, Cohen, Mukherjee, Tremblay, Debatis, Beamer, Dmitriev, Curiel, Shoemaker, Tzipori

A Broadly Applicable Therapeutic Platform that Employs a Simple VHH-Based Neutralizing Agent (VNA) and a Universal Effector Antibody (efAb) to Replicate the Pathogen Neutralization and Serum Clearance Functions of Polyclonal Antibodies

 

Mukherjee, Tremblay, Debatis, Ofori, Baldwin, Boucher, Reilly, Bedenice, Schmidt, Tzipori, Shoemaker, Feng, Leysath, Leppla, Vance, Mantis, Kashentseva, Dmitriev, Curiel

Identification, Characterization, and Cloning of Polypeptide N-acetylgalactosaminyl Transferase 4 of Cryptosporidium parvum

 

DeCicco and Ward

Identification of New Therapeutic Targets for Schistosomiasis using RNAi

 

Da’darah, Krautz-Peterson, Wang, Skelly

Neutrophils in Pulmonary Tuberculosis

 

Major and Beamer

The Intestinal Microbiota, Microbial Translocation and Inflammation in Chronic HIV Infection

 

Dinh, Volpe, Duffalo, Kane, Wanke, Ward

The Expression of Protective Capsular Polysaccharides by the Opportunistic Pathogen A. baumannii responds Phenotypically to Antibiotic Stress

 

Geisinge and Isberg

Phenotypic Specialization of Y. pseudotuberculosis within Microcolonies

 

Davis and Isberg

Host Cell Contribution to Type III Secretion in Yersinia pseudotuberculosis

 

Sheahan and Isberg

Subversion of the Host Cell Cycle by Legionella pneumophila

 

De Jesús Díaz and Isberg

Malaria Heat Shock Protein 101 (HSP101) is a Substrate of Plasmodium falciparum Signal Peptide Peptidase; Identification of a Novel Therapeutic Target

 

Baldwin and Chishti

Single Molecule Assays for Early Breast Cancer Detection

 

Baig, Schubert and Walt

A Novel Regenerative Therapeutic Strategy to Reverse Advanced Heart Failure in Chronic Chagas Disease and Other Cardiomyopathies

 

Salvador, Aridgides, Perrin

SiMoAs for the Ultra-Sensitive Detection of the Host Immune Response to Microbial Infections

 

Gaylord, Wu, Dinh, Milutinovic, Abdul-Aziz, Walt

Combinatorial-Designed Lipid Nanoparticles for Intracellular Delivery of Biomacromolecular Therapeutics

 

Wang and Xu

Versatile Substrates and Probes for IgA1 Protease Activity

 

Choudary and Kritzer

A Novel Chimeric Vaccine against Clostridium difficile Infection

 

Sun, Wang, Nie, Kim, Schmidt, Tzipori

A VHH-based Neutralizing Agent (VNA) Targeting Both TcdA and TcdB Toxins Protects Mice and Gnotobiotic Piglets from the Pathology of Clostridium Difficile Infection

 

Schmidt; Tremblay; Sun; Kim; Liu; Wang; Shi; Sheoran; Feng; Shoemaker; Tzipori
Tufts Comparative Pathology Services and Animal Histology CoreRichey