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This event focused on Tufts' strength in translational research: applying discovery with topics on the four phases of translational research, as well as poster presentations.

Thursday, November 29, 2007

Jean Mayer USDA Human Nutrition Research Center on Aging
711 Washington Street
Boston, MA 02111

Lightning Talks

Identification: Finding Genetic and Protein Markers for Disease
Implementation: Bringing New Technologies to Clinical Use
Intervention: Halting and Reversing the Progress of Disease
Prevention: Stopping Disease Before it Starts

Research Presentations

Moderated by Diana Bianchi 

From Bench to Bytes to Baby: A Translational Approach to Human Fetal Development
Diana Bianchi
Neuroscience to SoftBots: New Technologies from Ancient Animals
Barry Trimmer
Shape Up Somerville: Changing Communities One Step at a Time
Christina Economos

Identification: Finding Genetic and Protein Markers for Disease

Moderated by Hans-Georg Klingemann 

Novel Biomarkers for the Early Detection of Acute Kidney Injury
Bertrand Jaber
Natriuretic Peptides in Spontaneous Canine and Feline Heart Disease
John Rush
Identification of Molecular Cardiovascular Disease Targets through Human Genetics
Gordon Huggins
The Role of Biorepositories in Identification of Disease Indicators or Sentinel Markers
Richard Friedberg
Translational Bioinformatics
Donna Slonim

Implementation: Bringing New Technologies to Clinical Use

Moderated by Donna Slonim 

Getting Novel Cellular Therapies to the Patient
Hans-Georg Klingemann
Cervical Biomechanics during Pregnancy
Michael House
Optical Technologies for Non-invasive Disease Diagnosis
Irene Georgakoudi
Implementing Technology into the OR
Caroline Cao

Intervention: Halting and Reversing the Progress of Disease

Moderated by Garry Welch 

Heart Failure Models: Estrogen and its Receptors in Cardiac Hypertrophy
Richard Patten
Spontaneous Animal Models of Obesity: Treatment Options
Lisa Freeman
Biological Screening for Smoking as a Deterrent
Douglas Brugge
Intervention to Improve Medication Adherence Related Communication Improves Communication, but not Adherence
Ira Wilson

Prevention: Stopping Disease Before It Starts

Moderated by Douglas Brugge

Preventing Cardiovascular Disease in CKD
Mark Sarnak
Innovative Strategies in the Management of Diabetes
Garry Welch
The Effects of Exercise Training on Functional Performance and Disability in the Elderly
Roger Fielding
Prevention of Functional Loss and Work Productivity Due to Depression
Debra Lerner

Diana Bianchi, MD
Diana Bianchi, MD Natalie V. Zucker Professor of Pediatrics, Obstetrics and Gynecology, Tufts University School of Medicine, and Vice Chair for Research, Department of Pediatrics, Floating Hospital for Children and Tufts–New England Medical Center. Dr. Bianchi’s laboratory focuses on prenatal genetics. She is studying fetal cells and DNA that cross into the maternal circulation and can be used for noninvasive prenatal diagnosis of genetic conditions. Remarkably, these cells persist in the mother’s blood and organs for decades after the birth of the child. This phenomenon, called fetal cell microchimerism, is associated with autoimmune diseases and may also be an important source of stem cells for repair of tissue injury in the mother.
Christina Economos, PhD
 Christina Economos, PhDNew Balance Chair in Childhood Nutrition and assistant professor, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University. Professor Economos’s research focus is on the interaction among diet, exercise, body composition, and aging, with an emphasis on techniques that accurately measure and interventions that optimally develop and preserve skeletal muscle and bone mass throughout the lifespan. Her expertise includes working effectively with diverse populations and communities, developing and applying behavior-change strategies with children and families to improve diet and physical activity, and crafting, implementing and evaluating nutrition education curricula.
 Barry Trimmer, PhD
 Barry Trimmer, PhDHenry Bromfield Pearson Professor of Natural Sciences, Department of Biology, Tufts University; with appointments in the Department of Biomedical Engineering, School of Engineering, and the departments of Neuroscience and Pharmacology and Experimental Therapeutics, School of Medicine. Professor Trimmer’s research focus is on the mechanisms by which soft-bodied animals control their movements. These ideas are being used to construct an entirely new generation of soft-material robots capable of carrying out tasks that are difficult or impossible with conventional technologies. In addition to his work on living systems, Professor Trimmer is the founder (2005) and director of the Tufts Biomimetic Devices Laboratory, which specializes in the application of found biological principles to the design and fabrication of such novel devices.


In vivo Antisense Oligonucleotide Reduction of NPC1 Expression as a Novel Mouse Model for Niemann Pick Type C Associated Liver Disease


Rimkunas, Graham, Crooke, Liscum

Activation of the Calcium Sensing Receptor Stimulates Serum Gastrin and Gastric Acid Secretion in Healthy Subjects


Ceglia, Harris, Rasmussen, Dawson-Hughes

Breast Cancer Metastasis to Bone: Modeling Angiogenesis in the CAM using Tissue Engineering Strategies



A Mouse Model of Human Breast Cancer Metastasis to Tissue-Engineered Bone


Faverman, Moreau, Anderson, Reagan, Kaplan, Rosenblatt

Mouse Models of Human Cancer Metastasis Revealing Osteotropism Gene Signatures


Goldstein, Anderson, Moreau, Rosenblatt

Silencing of a Stem Cell Differentiation Gene (APRIN) in Prostate and Breast Cancers: Promoter Methylation and Microrna Clinical Studies


Pilichowska, Denes, Kyu Kim, Makarovskiy, Carpinito, Geck

Apoptosis in Response to Inhibition of Dipeptidyl Peptidase 2 Defines Low Risk Chronic Lymphocytic Leukemia


Danilov, Danilova, Klein, Huber

Transfection with mRNA for CD19 Specific Chimeric Antigen Receptor Restores NK Cell Mediated Killing of CLL Cells


Boissel, Betancur, Tuncer, Weitzman, Klingemann

Variable Contribution of Different Monoclonal Antibodies to NK Cell-Mediated ADCC Against Primary CLL Cells


Weitzman, Klingemann, Betancur, Boissel, Rabinowitz

Modulation of Lung Molecular Biomarkers by β-Carotene in the Physicians’ Health Study


Liu, Gaziano, Mucci, Wang, Zhang

Inhibitors of STAT3 Prevent Proliferation of Brain Tumor Stem Cells


Sherry, Reeves, Wu, Cochran

G Protein-Activated Inward Rectifier Potassium Channel 4 is a Regulateable Protein; Its Role in Autonomic Neuropathy in Type I Diabetes


Zhang, Park, Madias, Aronovitz, Karas, Galper

Simvastatin Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E Knockout Mice


Zhang, Naggar, Moulton, Park, Galper

Myosin Phosphatase-Rho Interacting Protein Modulation of Vascular Smooth Muscle Phenotype


Crochiere and Surks

Morphometric Measurements and Insulin-Like Growth Factor in Cats with Spontaneously-Occurring Hypertrophic Cardiomyopathy


Yang, Freeman, Rush

The Obesity Paradox in Dogs with Spontaneously-Occurring Heart Failure


Slupe, Freeman, Rush

Relationship between Cachexia and Lymphocyte Subpopulations and Hematologic Parameters in Dogs with Spontaneously-Occurring Congestive Heart Failure


Freeman and Rush

A Comparison of Oral Versus Transdermal Atenolol Administration in Cats


MacGregor, Rush, Rozanski, Boothe, Belmonte, Freeman

Lipid Lowering by Pravastatin Decreases Premature Ventricular Contractions and Ventricular Tachycardia: Gαi2, a Possible Molecular Marker for Predisposition to Arrhythmia


Welzig, Park, Naggar, Karas, Estes, Galper

Preliminary Foundation for in vitro Autosomal-Dominant Polycystic Kidney Disease Model


Rudym, Kaplan, Perrone

Mitochondrial Membrane Potential in Single Cells in Chronic Kidney Disease – Application of the Live Cell Array


Sathi, Padala, Rao, Demello, Arvold, Wikstrom, Molina, Haigh, Balakrishnan, Shirihai

Comparative Analysis of Urinary Biomarkers for the Early Detection of Acute Kidney Injury (AKI) Following Cardiopulmonary Bypass (CPB)


Liangos, Perianayagam, Kolyada, Tighiouart, MacKinnon, Wald, Han, Bonventre, Jaber

Proteomic Research and Services of the Tufts Proteomic Core Facility



STAT Decoy Oligonucleotide Administration Decreases Airway Inflammation and AHR in Allergic Asthma


Simeone-Penney and Simon

Nucleic Acid Microsphere Arrays for Respiratory Pathogen Analysis


Hayman and Walt

Intra-Oral Biofilms in the Complete Denture-Wearing Patient



Substance P Stimulates Human Mast Cells and Together They Activate T Cells: Inhibition by Luteolin


Kempuraj, Tagen, Iliopoulou, Clemons, Vasiadi, Boucher, House, Wolfberg, Theoharides

Microsphere-Based Cytokine Array for Salivary Diagnostics


Blicharz and Walt

Subtilase Cytotoxin (SubAB), a Newly-discovered Cytotoxin Produced by Certain Shiga Toxin-producing Escherichia coli (STEC) Induces a Stress Response in the Endoplasmic Reticulum


Wolfson, May, Thorpe, Jandhyala, J. Paton, A. Paton

Tufts Center for Integrated Tissue Engineering: Translational 3D Human Tissues for Drug Discovery


Egles, Shamis, Garlick

Cell Penetrating Peptide for Delivery of DNA, siRNA and Quantum Dots in vitro and in vivo


Johnson, Cashman, Kumar-Singh

Pomegranate Juice Does Not Impair Clearance of Oral or Intravenous Midazolam: Comparison with Grapefruit Juice


Farkas, Oleson, Zhao, Harmatz, Zinny, Court, Greenblatt

The Effect of Ritonavir and Chronic Viral Hepatitis on Cytochrome 3A Activity in HIV Infected Patients


Oleson, Knox, von Moltke, Kaufman, Greenblatt

Sleep Duration and Overweight in Early Elementary School Children


Hennessy, Kuder, Goldberg, Must, Sacheck, Economos

Children’s Multiple Representation of Their Ideas about Science



Transforming Science Learning in the Elementary Grades Through LEGO™ Engineering Design


Jarvin, Rogers, Bethke Wendell, Wright

The Child and Adolescent Scale of Participation (CASP): Further Psychometric Testing



Translating Community-Based Asthma Research in Boston Chinatown into a Community-Based Program


Palella, Chin, Lane, Brugge

A Model for Clinical Evaluation of Perioperative Analgesia in the Rabbit


Karas, Weaver, Andrutis, Blaze

Bioinformatics Identifies 107 Candidate Transcription Factors Involved in Fat Storage


Lane, Parnell, Ordovas

Central Dopamine Deficits as Markers for Dietary Obesity Predisposition


Geiger, Frank, Caldera-Siu, Beinfeld, Pothos

Exposure to Low Frequency Magnetic Fields Alters Catecholamine Exocytosis


Saveriades, Dunlap, Theoharides, Sergiadis, Pothos

Chronic Morphine Exposure in Peripubertal Female Rats Results in Altered Opioid Sensitivity and Tolerance in Their Offspring


E. Byrnes, Babb, Scanlan, J. Byrnes

Cell Cycle Re-entry and the Role of Molecular Chaperones in β-Amyloid Laden Skeletal Muscle Cells and Alzheimer’s Disease Brain


Kumar, Fu, Lee, Querfurth

Changes in Expression and Chromatin Structure of the Mental Retardation Gene Jarid1c in Neural Differentiation


Xu, Arnold , Disteche

Assessment of Sleep Disorders in Patients with Chronic Orofacial Pain


Lobo Lobo, Chandwani, Kulich, Mehta, Scrivani

Gold Nanocatalysts for Clean Energy Production


Flytzani-Stephanopoulos, Deng, Si, Zhai

Detection of Biomolecules by Magnetic Reporting of Magnetically Labeled Nanorods


Harrah, Xie, Oh, Naughton, Sun, Guertin, Goldberg

Experimental Techniques for Understanding Chemical Mechanical Polishing


Gray, Vlahakis, Braun, Rogers, Manno

Reproductive Experience Increases Neural Prolactin Receptor and Socs-1 and -3 mRNA Expression in the Rostral Hypothalamus of Female Rats


Bridges, Anderson,
van der Ancker, Grattan

Arginine Vasopressin Antagonism Affects Maternal Aggression and the Retention of Maternal Behavior in Lactating Rats


Nephew and Bridges

The Mechanical Properties of Caterpillar Cuticle


Lin, Dorfmann, Trimmer

Occipitocervical Fusion in a Dog Using Locking Buttress Plate Fixation and Synthetic Bone Graft (rhBMP-2 CRM)


Boudrieau and Faissler

Predictors of Mobility-Disability in Older Adults: The Role of Lower Extremity Muscle Strength and Body Composition


Reid, Naumova, Carabello, Phillips, Frontera, Fielding

Slow Rate of Neuromuscular Activation Contributes to Impaired Movement Acceleration and Peak Power in Mobility-Limited Older Adults


Clark, Patten, Reid, Carabello, Phillips, Fielding

Effect of Almond Skin Polyphenols and Quercetin on Human LDL and Apolipoprotein B-100 Oxidation and Conformation


Chen and Blumberg

Almond Consumption Reduces Oxidative DNA Damage and Lipid Peroxidation in Male Smokers


Chen, Jia, Li, Blumberg

Rock1, Rock2 and a Little Rock: Can a Little Gene Make the Difference?

Montefusco, Wooten, Huggins