Postdoc Publications

If you have a recently published paper or one in press, please contact Dan Jay, Postdoctoral Officer, at to share your accomplishments.

List of Recent Publications

October 2015


Bigalke JM, Heldwein EE. 2015. Structural basis of membrane budding by the nuclear egress complex of herpesviruses. EMBO J. Epub ahead of print.

Coburn JM, Na E, Kaplan DL. 2015. Modulation of vincristine and doxorubicin binding and release from silk films. J Control Release Epub ahead of print.

Hardy JG, Khaing ZZ, Xin S, Tien LW, Ghezzi CE, Mouser DJ, Sukhavasi RC, Preda RC, Gil ES, Kaplan DL,

Schmidt CE. Into the groove: instructive silk-polypyrrole films with topographical guidance cues direct DRG neurite outgrowth. J Biomater Sci Polym Ed. 28:1-16.

Petnicki-Ocwieja T, Kern A, Killpack TL, Bunnell SC, Hu LT. 2015. Adaptor protein-3-mediated trafficking of TLR2 ligands controls specificity of inflammatory responses but not adaptor complex assembly. J Immunol. Epub ahead of print.

Shultz MJ, Brumberg A, Bisson PJ, Shultz R. 2015. Producing desired ice faces. Proc Natl Acad Sci USA Epub ahead of print.

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September 2015


Abbott RD, Borowsky FE, Quinn KP, Bernstein DL, Georgakoudi I, Kaplan DL. 2015. Non-invasive Assessments of Adipose Tissue Metabolism In Vitro. Ann Biomed Eng. Epub ahead of print

Applegate MB, Coburn J, Partlow BP, Moreau JE, Mondia JP, Marelli B, Kaplan DL, Omenetto FG. 2015. Laser-based three-dimensional multiscale micropatterning of biocompatible hydrogels for customized tissue engineering scaffolds. Proc Natl Acad Sci USA Epub ahead of print.

Chen WS, Cao Z, Krishnan C, Panjwani N. 2015. Verteporfin without light stimulation inhibits YAP activation in trabecular meshwork cells: Implications for glaucoma treatment. Biochim Biophys Res Commun. Epub ahead of print.

Chen Y, Lin Y, Davis KM, Wang Q, Rnjak-Kovacina J, Li C, Isberg RR, Kumamoto CA, Mecsas J, Kaplan DL 2015. Robust bioengineered 3D functional human intestinal epithelium. Sci Rep. 5: 13708.

Hardy JG, Ghezzi CE, Saballos RJ, Kaplan DL, Schmidt CE. 2015.. Supracolloidal assemblies as sacrificial templates for porous silk-based biomaterials. Int J Mol Sci.16: 20511-20522.

Isaac DT, Laguna RK, Valtz N, Isberg RR. 2015. MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth. Proc Natl Acad Sic USA Epub ahead of print.

Ramirez HA, Liang L, Pastar I, Rosa AM, Stojadinovic O, Zwick TG, Kirsner RS, Maione AG, Garlick JA, Tomic-Canic M. 2015. Comparative genomic, microRNA, and tissue analyses reveal subtle differences between non-diabetic and diabetic foot skin. PLoS One 10 : e0137133.

Yigit S, Dinjaski N, Kaplan DL. 2015. Fibrous proteins: At the crossroads of genetic engineering and biotechnological applications. Biotechnol Bioeng. Epub ahead of print.

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August 2015


Bou Ghanem EN, Clark S, Roggensack SE, McIver SR, Alcaide P, Haydon PG, Leong JM. 2015. Extracellular adenosine protects against Streptococcus pneumoniae lung infection by regulating pulmonary neutrophil recruitment. PLoS Pathog. 11: e1005126.

Dalia AB, Seed KD, Calderwood SB, Camilli A. 2015. A globally distributed mobile genetic element inhibits natural transformation of Vibrio cholerae. Proc Natl Acad Sci USA Epub ahead of print.

Guo X, Wang SB, Xu H, Ribic A, Mohns EJ, Zhou Y, Zhu X, Biederer T, Crair MC, Chen B. 2015. Nat Comm. Epub ahead of print.

Kim JC, Mirkin SM. 2015. Putting the brakes on Huntington Disease in a mouse experimental model. PLoS Genet. 11: e1005409.

Rozati M, Barnett J, Wu D, Handelman G, Saltzman E, Wilson T, Li L, Wang J, Marcos A, Ordovás JM, Lee YC, Meydani M, Meydani SN. 2015. Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial. Nutr Metab (London) Epub ahead of print.

Stoppel WL, Kaplan DL, Black LD 3rd. 2015. Electrical and mechanical stimulation of cardiac cells and tissue constructs. Adv Drug Deliv Rev. Epub ahead of print.

Guo X, Wang SB, Xu H, Ribic A, Mohns EJ, Zhou Y, Zhu X, Biederer T, Crair MC, Chen B. 2015. Nat Comm. Epub ahead of print.

Tao H, Marelli B, Yang M, An B, Onses MS, Rogers JA, Kaplan DL, Omenetto FG. 2015. Inkjet printing: Inkjet printing of regenerated silk fibroin: From printable forms to printable functions. Adv Mater. 27: 4245.

Wu D, Milutinovic MD, Walt DR. 2015. Single molecule array (Simoa) assay with optimal antibody pairs for cytokine detection in human serum samples. Analyst Epub ahead of print.

Yang X, Lin YP, Heselpoth RD, Buyuktanir O, Qin J, Kung F, Nelson DC, Leong JM, Pal U. 2015. Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection. Cell Microbiol. Epub ahead of print.

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July 2015


Dokukin M, Sokolov I. 2015. High-resolution high-speed dynamic mechanical spectroscopy of cells and other soft materials with the help of atomic force microscopy. Sci Rep.  5: 12630.

Liu Z, Quinn KP, Speroni L, Arendt L, Kuperwasser C, Sonnenschein C, Soto AM, Georgakoudi I. 2015. Rapid three-dimensional quantification of voxel-wise collagen fiber orientation. Biomed Opt Express 6: 2294-2310.

Lobikin M, Paré JF, Kaplan DL, Levin M. 2015. Selective depolarization of transmembrane potential alters muscle patterning and muscle cell localization in Xenopus laevis embryos. Int J Dev Biol. Epub ahead of print.

McDonough E, Kamp H, Camilli A. 2015. Vibrio cholerae phosphatases required for the utilization of nucleotides and extracellular DNA as phosphate sources. Mol Microbiol. Epub ahead of print.

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June 2015


Bigalke JM, Heldwein EE. 2015. The great (nuclear) escape: new insights into the role of the nuclear egress complex of herpesviruses. J Virol. Epub ahead of print.

Haenssler E, Ramabhadran V, Murphy CS, Heidtman MI, Isberg RR. 2015. Endoplasmic reticulum tubule protein Reticulon 4 associates with the L. pneumophila vacuole and with translocated substrate Ceg9. Infect Immun. Epub ahead of print.

Luo C, Pietruska JR, Sheng J, Bronson RT, Hu MG, Cui R, Hinds PW. 2015. Expression of oncogenic BRAFV 600E in melanocytes induces Schwannian differentiation in vivo. Pigment Cell Melanoma Res. Epub ahead of print.

McGehee AM, Moss BJ, Juo P. 2015. The DAF-7/TGF-β signaling pathway regulates abundance of the

Caenorhabditis elegans glutamate receptor GLR-1. Mol Cell Neurosci. Epub ahead of print

Schubert SM, Arendt LM, Zhou W, Baig S, Walter SR, Buchsbaum RJ, Kuperwasser C, Walt DR. 2015. Ultra-sensitive protein detection via single molecule arrays towards early stage cancer monitoring. Sci Rep. 5: 11034.

Tao H, Marelli B, Yang M, An B, Onses S, Rogers JA, Kaplan DL, Omenetto FG. 2015. Inkjet printing of regenerated silk fibroin: From printable forms to printable functions. Adv Mater. Epub ahead of print.

Wronski A, Arendt LM, Kuperwasser C. 2015. Humanization of the mouse mammary gland. Methods Mol Biol. 1293: 173-186.

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May 2015


Abbott RD, Kaplan DL. 2015. Strategies for improving the physiological relevance of human engineered tissues. Trends Biotechnol. Epub ahead of print.

Brown JP, Galassi TV, Stoppato M, Schiele NR, Kuo CK 2015. Comparative analysis of mesenchymal stem cell and embryonic tendon progenitor cell response to embryonic tendon biochemical and mechanical factors. Stem Cell Res Ther. 6: 89

Burke AR, Miczek KA. 2015. Escalation of cocaine self-administration in adulthood after social defeat of adolescent rats: role of social experience and adaptive coping behavior. Psychopharmacology (Berl) Epub ahead of print.

Fowler T, Garruss AS, Ghosh A, De S, Becker KG, Wood WH, Weirauch MT, Smale ST, Aronow B, Sen R, Roy AL. 2015. Divergence of transcriptional landscape occurs early in B cell activation. Epigenetics Chromatin. 8: 20.

Lin S, Ryu S, Tokareva O, Gronau G, Jacobsen MM, Huang W, Rizzo DJ, Li D, Staii C, Pugno NM, Wong JY, Kaplan DL, Buehler MJ. 2015. Predictive modelling-based design and experiments for synthesis and spinning of bioinspired silk fibres. Nat Comm. 6: 6892.

McDowell GS. 2015. A Response to the NIH RFI “Sustaining the Biomedical Workforce and a Potential Emeritus Award for Senior Researchers”. The Winnower. 2:e143189.95895

McDowell GS. 2015. A Response to the NIH RFI “Optimizing Funding Policies and Other Strategies”. The Winnower. 2:e143136.63273

McDowell GS. 2015. Faculty Resistance to Reform: Challenges to changing postdoc benefits at University of Maryland. The Winnower. 2:e142955.54234

Pai VP. 2015. A response to NIH request for information on optimizing funding policies and other strategies to improve the impact and sustainability of biomedical research. The Winnower. 2:e143135.51381

Pai VP, Lemire JM, Paré JF, Lin G, Chen Y, Levin M. 2015. Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci. 35(10): 4366-85.

Rnjak-Kovacina J, Wray LS, Burke KA, Torregrosa T, Golinski JM, Huang W, Kaplan DL. 2015. Lyophilized silk sponges: A versatile biomaterial platform for soft tissue engineering. ACS Biomater Sci Eng. 1 :260-270.

Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. 2015. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices in vitro and in vivo. J Neurosci. 35: 8291-8286.

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April 2015


Abbott RD, Raja WK, Wang RY, Stinson JA, Glettig DL, Burke KA, Kaplan DL. 2015. Long term perfusion system supporting adipogenesis. Methods. Epub ahead of print.

Algarrahi K, Franck D, Ghezzi CE, Cristofaro V, Yang X, Sullivan MP, Chung YG, Affas S, Jennings R, Kaplan DL, Estrada CR Jr, Mauney JR. 2015. Acellular bi-layer silk fibroin scaffolds support functional tissue regeneration in a rat model of onlay esophagoplasty. Biomaterials 53: 149-159.

Asrat S, Davis KM, Isberg RR. 2015. Modulation of the host innate immune and inflammatory response by translocated bacterial proteins. Cell Microbiol. Epub ahead of print.

Cilla R, Mechery V, Hernandez de Madrid B, Del Signore S, Dotu I, Hatini V. 2015. Segmentation and tracking of adherens junctions in 3D for the analysis of epithelial tissue morphogenesis. PLoS Comput Biol. 11: e1004124.

Dokukin ME, Guz NV, Woodworth CD, Sokolov I. 2015. Emerging of fractal geometry on surface of human cervical epithelial cells during progression towards cancer. J New Phys. 17: pii: 033019.

Hanson E, Armbruster M, Cantu D, Andresen L, Taylor A, Danbolt NC, Dulla CG. 2015. Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex. Glia. Epub ahead of print.

Jia L, Ghezzi CE, Kaplan DL. 2015. Optimization of silk films as substrate for functional corneal epithelium growth. J Biomed Mater Res B Appl Biomater. Epub ahead of print.

Lin Y, Wang S, Chen Y, Wang Q, Burke KA, Spedden EM, Staii C, Weiss AS, Kaplan DL. 2015. Electrodeposited gels prepared from protein alloys. Nanomedicine (London) 5: 803-814.

Lin YP, Bhowmick R, Coburn J, Leong JM. 2015. Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete. Cell Microbiol. Epub ahead of print.

Polka JK, Krukenberg KA, McDowell GS. 2015. A call for transparency in tracking student and postdoc career outcomes.  Mol Cell Biol. 26:  1413-1415.

Seib FP, Coburn J, Konrad I, Klebanov N, Jones GT, Blackwood B, Charest A, Kaplan DL, Chiu B. 2015. Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo. Acta Biomater. Epub ahead of print.

Stoppel WL, Hu D, Domian IJ, Kaplan DL, Black LD. 2015. Anisotropic silk biomaterials containing cardiac extracellular matrix for cardiac tissue engineering. Biomed Mater. 10: 034105.

Yuan J, Benway CJ, Bagley J, Iacomini J. 2015. MicroRNA-494 promotes cyclosporine-induced nephrotoxicity and epithelial to mesenchymal transition by inhibiting PTEN. Am J Transplant. Epub ahead of print.

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March 2015


Anderson PG, Kainerstorfer JM, Sassaroli A, Krishnamurthy N, Homer MJ, Graham RA, Fantini S. 2015. Broadband optical mammography: chromophore concentration and hemoglobin saturation contrast in breast cancer. PLoS One 10: e0117322.

Dokukin ME, Guz NV, Woodworth CD, Sokolov I. 2015. Emergence of fractal geometry on the surface of human cervical epithelial cells during progression towards cancer. New J Phys. 17.

Garafalo SD, Luth ES, Moss BJ, Monteiro MI, Malkin E, Juo P. 2015. The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Mol Cell Biol. Epub ahead of print.

Lobo D, Feldman EB, Shah M, Malone TJ, Levin M. 2015. A bioinformatics expert system linking functional data to anatomical outcomes in limb regeneration. Regeneration 1: 37-56.

Wang S, Ghezzi CE, White JD, Kaplan DL. 2015. Co-culture of dorsal root ganglion neurons and differentiated human corneal stromal stem cells on silk-based scaffolds. J Biomed Mat Res A Epub ahead of print.

McDowell GS, Polka J. 2015. A Call for the Voices of Early Career Researchers. The Winnower.  2:e142548.85537

Mitchell SL, Ismail AM, Kenrick SA, Camilli A. 2015. The VieB auxiliary protein negatively regulates the VieSA signal transduction system in Vibrio cholerae BMC Microbiol. 15: 387.

Mordwinkin N, Nicholson J, McDowell GS, Cox L. 2015. Advice for PhD Students: Tips From Professors, Startup Founders, and Industry Professionals. The Winnower. 2:e142628.87584

Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. 2015. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Rep. Epub ahead of print

Ng SK, Higashimori H, Tolman M, Yang Y 2015. Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis. Exp Neurol. Epub ahead of print.

Shainheit MG, Valentino MD, Gilmore MS, Camilli A. 2015. Mutations in pneumococcal cpsE generated via in vitro serial passaging reveals a potential mechanism of reduced encapsulation utilized by a conjunctival isolate. J Bacteriol. Epub ahead of print.

Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ. 2015. KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proc Natl Acad Sci USA Epub ahead of print.

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February 2015


An B, Tang-Schomer MD, Huang W, He J, Jones JA, Lewis RV, Kaplan DL. 2015. Physical and biological regulation of neuron regenerative growth and network formation on recombinant dragline silks. Biomaterials 48: 137-146.

 Geisinger E, Isberg RR 2015. Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii. PLoS Pathog 11: e1004691.

Jackson FR, Ng FS, Sengupta S, You S, Huang Y. 2015. Glial cell regulation of rhythmic behavior. Methods Enzymol. 552: 45-73.

 Kainerstorfer JM, Sassaroli A, Tgavalekos KT, Fantini S. 2015. Cerebral autoregulation in the microvasculature measured with near-infrared spectroscopy. J Cereb Blood Flow Epub ahead of print.

Pai VP, Hernandez LL, Stull MA, Horseman ND. 2015. The Type 7 Serotonin Receptor, 5-HT 7, Is Essential in the Mammary Gland for Regulation of Mammary Epithelial Structure and Function. Biomed Res Int. 2015: 364746.

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January 2015


de Madrid BH, Greenberg L, Hatini V. 2015. RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs. Dev Biol. Epub ahead of print.

Di Buduo CA, Wray LS, Tozzi L, Malara A, Chen Y, Ghezzi CE, Smoot D, Sfara C, Antonelli A, Spedden E, Bruni G, Staii C, De Marco L, Magnani M, Kaplan DL, Balduini A. 2015. Programmable 3D silk bone marrow niche for platelet generation ex vivo and modeling of megakaryopoiesis pathologies. Blood Epub ahead of print.

Liu L, Peritore C, Ginsberg J, Kayhan M, Donmez G. 2015. SIRT3 Attenuates MPTP-Induced Nigrostriatal Degeneration Via Enhancing Mitochondrial Antioxidant Capacity. Neurochem Res. Epub ahead of print.

Nakamura Y, Darnieder LM, Deeb TZ, Moss SJ. 2015. Regulation of GABAARs by phosphorylation. Adv Pharmacol. 72:97-146.

Reverri EJ, LaSalle CD, Franke AA, Steinberg FM. 2015. Soy provides modest benefits on endothelial function without affecting inflammatory biomarkers in adults at cardiometabolic risk. MNFR. 59(2): 323-33.

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