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Posted: February 11, 2016

C4 Therapeutics is seeking highly motivated and innovative medicinal chemists to contribute to the development of small molecule targeted therapeutics. Candidates should be highly motivated and be able to effectively work within target-focused project teams. Ideal candidates will have in depth knowledge of chemical synthesis and a proven track record of advancing small molecules across stage gates from Hit ID through clinical candidate selection. Candidates must be adaptable to a fast-paced and dynamic environment, with a strong desire to succeed.


  • Develop and execute synthetic routes of target molecules, including work up, purification, isolation, and characterization of products.  Develop scalable routes of preclinical drug-candidates.
  • Optimize drug candidates through interpretation of complex data sets through iterative SAR.
  • Utilize computational approaches, including structure guided drug design, to optimize chemical leads.
  • Work with a multidisciplinary groups to initiate and advance drug discovery programs.
  • Manage external study execution at contract research organizations and engage with extramural industry and academic collaborators.
  • Contribute to the writing of patents, scientific presentations, and publications
  • Critically analyze data and communicate findings effectively to multidisciplinary team members and senior management.


  • Ph.D. in organic or medicinal chemistry.
  • Minimum of 5 years of relevant experience, preferably in the biopharma/pharma setting.
  • Proven scientific track record of advancing small molecules through stage gate milestones from HID through candidate selection.
  • Expertise in synthetic organic chemistry, including methodologies, transformations, and mechanisms.
  • Demonstrated expertise in multi-step synthesis and strong knowledge of techniques related to purification and characterization of organic compounds (NMR, MS, HPLC, etc.).
  • Ability to interpret complex datasets to optimize chemical leads through SAR.
  • Ability to work independently and apply experience and knowledge to solve difficult synthetic challenges and provide useful guidance to other chemists on the project team.
  • Strong motivation, independence, and ability to work in a high-pace multidisciplinary, matrix environment with minimal supervision.
  • Demonstrated ability to effectively manage and mentor research staff.
  • Excellent interpersonal as well as oral and written communication skills required.

Interested candidates: Please send your resume, CV and any supplemental materials to