Scientists/Senior Scientists: In vitro Pharmacology
Posted: February 11, 2016
C4 Therapeutics is seeking highly motivated and innovative scientists to contribute to the development of small molecule targeted therapeutics. Candidates should be highly motivated and be able to effectively work within target-focused project teams. This position requires scientific knowledge and demonstrated success in the various aspects of lead discovery, including cell-based and biochemical assay development, biophysical assay development, and miniaturization and development of high throughput assays to support lead optimization. Candidates must be adaptable to a fast-paced and dynamic environment, with a strong desire to succeed.
Develop, validate, implement and execute biochemical and biophysical assays for medium and high throughput screening to support target identification and lead optimization for small molecule drug discovery.
Implement novel in vitro screening strategies and design screening and counter screening funnels to evaluate affinity, potency, and mechanism of action of drug candidates.
Monitor assay quality and troubleshoot issues with assay performance.
Work with a multidisciplinary groups (Biology, Medicinal Chemistry, and Pharmacology) to initiate and advance drug discovery programs.
Critically analyze data and communicate findings effectively to multidisciplinary team members and senior management.
Ph.D. in Biochemistry, Pharmacology or a related field.
Minimum of 5 years of relevant experience, preferably in the biopharma/pharma setting.
Proven scientific track record in the development and execution of both biochemical and cell based assays to support drug discovery.
Demonstrated knowledge of biochemical and biophysical assay formats and readouts.
Strong motivation, independence, and ability to work in a high-pace multidisciplinary, matrix environment with minimal supervision.
Strong problem solving skills.
Demonstrated ability to effectively manage and mentor research staff.
Excellent interpersonal as well as oral and written communication skills required.