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Posted: February 11, 2016

C4 Therapeutics is seeking highly motivated and innovative scientists to contribute to the development of small molecule targeted therapeutics. Candidates should be highly motivated and be able to effectively work within target-focused project teams. This position requires candidates to be able to design and conduct research, including the design and execution of key biological experiments focused on the elucidation of target mode of action, development of pathway-specific biomarkers of activity, identification and use of suitable pre-clinical models, and the development and evaluation of clinical hypotheses. Candidates must be adaptable to a fast-paced and dynamic environment, with a strong desire to succeed.


  • Independently design and execute experiments to advance small molecule drug discovery programs.
  • Identify and implement target- and cell-based assays to identify/validate compound mechanism of action, inform on target and pathway modulation, and inform on cellular response to target inhibition.
  • Work with a multidisciplinary groups (Medicinal Chemistry, Biochemistry, and Pharmacology) to initiate and advance drug discovery programs.
  • Manage external study execution at contract research organizations and engage with extramural industry and academic collaborators.
  • Critically analyze data and communicate findings effectively to multidisciplinary team members and senior management.


  • Ph.D. in Biology or a related field.
  • Minimum of 5 years of relevant experience, preferably in the biopharma/pharma setting.
  • Knowledge of drug discovery from target identification through clinical candidate selection.
  • In depth knowledge of oncology targets and molecular pathways and the ability to translate this knowledge into drug discovery and development endpoints.
  • Strong motivation, independence, and ability to work in a high-pace multidisciplinary, matrix environment with minimal supervision.
  • Experience working with academic collaborators and contract research organizations is preferred.
  • Strong problem solving skills.
  • Demonstrated ability to effectively manage and mentor research staff.
  • Excellent interpersonal as well as oral and written communication skills required.

Interested candidates: Please send your resume, CV and any supplemental materials to