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Location Framingham, Massachusetts
Job Category Laboratory
Requisition Number POS_75043850-1/
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Description
A post-doctoral scientist is sought to join a multidisciplinary Translational Neuroscience Team
to develop biomarkers for neurodegenerative diseases. Specifically, the individual will be
responsible for developing and implementing mass spectrometry-based methods to identify an
innovative and transformative solution for Parkinson’s disease.

Parkinson’s disease is the second most frequent common neurodegenerative disease affecting
1M people in the US. There is no cure or disease-modifying therapy for Parkinson’s, and this
may be due in part to our inability to monitor biological markers of disease. Currently, patients
are diagnosed, cared for, and assigned to clinical trials based on medical history and physical
exam. The postdoctoral fellow will be responsible for defining novel biomarkers to evaluate
disease progression and therapeutic response.

Qualifications
The position is for a highly motivated individual with a Ph.D. in Biochemical or Biological
Sciences, Analytical Chemistry with 0-2 years post-doctoral experience. Prior experience
in mass spectrometry, biomarker research and/or computational systems is required.
Experience in the area of MS-based proteomics and metabolomics and familiarity with
operating proteomics and metabolomics software are desired. The primary responsibility will
be the development and execution of mass spectrometry methods to profile peptides, lipids
and/or metabolites in human biospecimens. Experience in enrichment and recovery techniques
for challenging protein mixtures is a plus. The candidate is expected to possess a good record
of scientific publications, strong analytical and organizational skills, self-motivation and the
ability to work well independently as well as in a team environment.

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